Research papers of the week – October 3, 2022

Joy Iyojo Itodo, Peter Ibrahim Rekwot, Tagang Aluwong, Lushaikyaa Allam, Kelvin Olutimilehin Jolayemi, Stephen Kyari, Kenneth Abah, Shettima Ibrahim, Mohammad Umar Dogara, Abdulrafiu Tayo Yusuf, Mohammad Makama Musa, Harirat Ladi Mundi, Hudu Ramalan Abdullahi

Theriogenology

Ministerial score = 140.0
Journal Impact Factor (2022) = 2.923 (Q1)

This study evaluated the ameliorative properties of Azanza garckeana in Bisphenol A-induced reproductive toxicities on weight, spermiogram, serum hormonal profile, sperm DNA integrity, histopathology of testes and brain tissues of rabbit bucks. Twenty-eight rabbit bucks, with live weight of 1.20–2.00 kg and aged 10–18 months. They were randomly divided into four groups of seven bucks each, group A was administered distilled water (1.5 mL) daily for 12 weeks, group B was administered Bisphenol A (100 mg/kg) for 5 consecutive days in a week for a period of 12 weeks, group C was administered Azanza garckeana (500 mg/kg) daily for 12 weeks and group D was pre-dosed with Bisphenol A (100 mg/kg) for 5 consecutive days in a week over 6 weeks period followed by Azanza garckeana (500 mg/kg) daily for another 6 weeks. Mean testicular weights differed significantly (p < 0.05) between group B (4.4 ± 0.23) when compared with groups A (8.0 ± 0.06), C (8.7 ± 0.19) and D (7.1 ± 0.18). There were significant differences (p < 0.05) in the mean reaction time, spermiogram, testosterone, follicle stimulating hormone, luteinising hormone and sperm DNA fragmentation index between Bisphenol A-exposed groups and treatment groups. On histopathology, there was testicular vacuolization, interstitial hemorrhage, reduction in spermatogenic cells following Bisphenol A exposure. There were layers of dense basophilic cells in the pineal and pituitary parenchymas. In conclusion, Bisphenol A has negative effects on reproduction but administration of Azanza garckeana may possess some therapeutic properties that can ameliorate such adverse effects.

DOI:10.1016/j.theriogenology.2022.08.023

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