Identification of accident scenarios involving scaffolding
Mariusz Szóstak, Bożena Hoła, Paweł Bogusławski
Automation in Construction
The aim of the undertaken research was to identify the most frequently repeated accident scenarios in relation to accidents that involve scaffolding. The source of knowledge was accident documentation containing information on the circumstances of accidents, as well as their course and consequences. As part of the research, an IT Database (ITD) was developed, which involved accidents that occurred in Poland over the past five years which were related to work on scaffolding. An original graphical, mathematical and IT process model was developed in order to enable a large set of accidents involving construction scaffolding to be studied. Due to the fact that every accident proceeds according to a different scenario, a map of possible accident scenarios was developed and presented in the form of a directed graph. Graph algorithms, including the Dijkstra algorithm, were used to build the IT model. Based on the information contained in the ITD, the course of the accident sequence was analysed in the proposed graph. The most probable accident scenarios, the probability of their occurrence, and the course of the critical path were determined. The obtained results constitute a starting point for estimating the occupational risk associated with working on scaffoldings.
10.1016/j.autcon.2021.103690
Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
Beata Tylińska, Benita Wiatrak, Żaneta Czyżnikowska, Aneta Cieśla-Niechwiadowicz, Elżbieta Gębarowska, Anna Janicka-Kłos
International Journal of Molecular Sciences
In the present paper, new pyrimidine derivatives were designed, synthesized and analyzed in terms of their anticancer properties. The tested compounds were evaluated in vitro for their antitumor activity. The cytotoxic effect on normal human dermal fibroblasts (NHDF) was also determined. According to the results, all the tested compounds exhibited inhibitory activity on the proliferation of all lines of cancer cells (colon adenocarcinoma (LoVo), resistant colon adenocarcinoma (LoVo/DX), breast cancer (MCF-7), lung cancer (A549), cervical cancer (HeLa), human leukemic lymphoblasts (CCRF-CEM) and human monocytic (THP-1)). In particular, their feature stronger influence on the activity of P-glycoprotein of cell cultures resistant to doxorubicin than doxorubicin. Tested compounds have more lipophilic character than doxorubicin, which determines their affinity for the molecular target and passive transport through biological membranes. Moreover, the inhibitory potential against topoisomerase II and DNA intercalating properties of synthesized compounds were analyzed via molecular docking.
10.3390/ijms22083825
