Research papers of the week – December 25, 2023

Rafał Ciaputa; Marcin Nowak; Stanisław Dzimira; Eleonora Brambilla; Małgorzata Kandefer-Gola; Alicja Tomaszek; Aneta Popiel-Kopaczyk; Piotr Dzięgiel; Valeria Grieco

Journal of Veterinary Research

Ministerial score = 200.0
Journal Impact Factor (2023) = 1.8 (Q2)

Introduction: Testin is a protein involved in cell mobility, adhesion and colony formation. In rats, testin presence has beenreported in the testes, and its possible role in spermatogenesis has been suggested. Studies in humans also suggest a possible roleof testin as a cancer suppressor protein. In the dog, which represents both an important pet species and a good animal model forstudying biological and pathological testicular processes, the presence of testin has never been reported. Material and Methods:In the present study, the expression of testin in foetal, prepubertal, adult and aged canine testes was investigated. Testes from5 adult and 3 aged dogs, from 2 one-month-old puppies and from 2 foetuses miscarried at the end of pregnancy wereimmunohistochemically examined with a commercial antibody against testin. Results: Testin was intensely expressed in Sertolicells in every testis examined. Spermatids were also positive for testin in mature dogs and in the testicular areas of the aged oneswhich were not atrophic. Weak expression of testin was also detected in all testes examined. Conclusion: The present study, thefirst demonstrating the presence of testin in canine testes, provides the basis for further dog–human comparative research and forstudies on the role of this protein in canine physiology, reproduction and testicular pathologies.

DOI:10.2478/jvetres-2023-0055

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