Research papers of the week – February 12, 2024

Marcin Szustak; Eliza Korkus; Rafał Madej; Arkadiusz Chworos; Grzegorz Dąbrowski; Sylwester Czaplicki; Efran Tabandeh; Gabriela Maciejewska; Maria Koziołkiewicz; Iwona Konopka; Anna Gliszczyńska; Edyta Gendaszewska-Darmach

ACS Medicinal Chemistry Letters

Ministerial score = 140.0
Journal Impact Factor (2023) = 4.2 (Q2)

Among lipids, lysophosphatidylcholines (LPCs) with various fatty acyl chains have been identified as potential agonists of G protein-coupled receptors (GPCRs). Recently, targeting GPCRs has been switched to diabetes and obesity. Concomitantly, our last findings indicate the insulin secretagogue properties of cis and trans palmitoleic acid (16:1, n-7) resulting from GPCR activation, however, associated with different signaling pathways. We here report the synthesis of LPCs bearing two geometrical isomers of palmitoleic acids and investigation of their impact on human pancreatic β cells viability, insulin secretion, and activation of four GPCRs previously demonstrated to be targeted by free fatty acids and LPCs. Moreover, molecular modeling was exploited to investigate the probable binding sites of tested ligands and calculate their affinity toward GPR40, GPR55, GPR119, and GPR120 receptors.

DOI:10.1021/acsmedchemlett.3c00263

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