Research papers of the week – January 03, 2022

Joanna Kwiecińska-Piróg, Jana Przekwas, Zuzanna Kraszewska, Alicja Sękowska, Sylwia Brodzka, Natalia Wiktorczyk-Kapischke, Katarzyna Grudlewska-Buda, Ewa Wałecka-Zacharska, Maciej Zacharski, Aneta Mańkowska-Cyl, Eugenia Gospodarek-Komkowska, Krzysztof Skowron

Vaccines

Ministerial score = 140.0
JIF Impact Factor (2020) = 4.422 (Q2)

(1) Background: In many infections, antibodies play a crucial role in controlling infection. In COVID-19, the dynamics of the immune system response to SARS-CoV-2 is not fully understood. (2) Methods: The study was conducted on 120 healthcare workers from Dr. Antoni Jurasz University Hospital No. 1 in Bydgoszcz, between June and December 2020. In all participants, IgA and IgG antibody serum concentrations were measured using the semi-quantitative Anti-SARS-CoV-2 ELISA test (Euroimmun). After vaccination, in January and February 2021, antibody levels were examined using the quantitative IgG Anti-SARS-CoV-2 Quantivac ELISA test (Euroimmun). (3) Results: During the whole study period, the SARS-CoV-2 infection was confirmed in 29 (24.2%) participants. In all infected participants, IgA and IgG antibodies were detectable after infection by semi-quantitative serological tests. Levels of antibodies were higher one month after the first dose in the convalescents than in the non-previously infected participants. In this second group, the level of antibodies increased significantly after the second dose of vaccines compared to the first dose. (4) Conclusions: The level of antibodies after the first dose of vaccine in the convalescents’ group is higher than in the SARS-CoV-2 non-infected group, but the differences disappear after the second vaccination.

DOI:10.3390/vaccines9121402

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