Phospholipid Derivatives of Cinnamic Acid Restore Insulin Sensitivity in Insulin Resistance in 3T3-L1 Adipocytes
Małgorzata Małodobra-Mazur, Dominika Lewoń, Aneta Cierzniak, Marta Okulus, Anna Gliszczyńska
Nutrients
Ministerial score = 140.0
JIF Impact Factor (2020) = 5.719
Background: Insulin resistance (IR) is a condition in which the physiological amount of insulin is insufficient to evoke a proper response of the cell, that is, glucose utilization. Metformin is the first choice for therapy, thanks to its glycemic efficacy and general tolerability. In addition, various natural compounds from plant extracts, spices, and essential oils have been shown to provide health benefits regarding insulin sensitivity. In the present study, we analyzed the effect of phospholipid derivatives of selected natural aromatic acids on insulin action and their potential use to overcome insulin resistance. Methods: The 3T3-L1 fibroblasts were differentiated into mature adipocytes; next, insulin resistance was induced by palmitic acid (16:0). Cells were further cultured with phenophospholipids at appropriate concentrations. To assess insulin sensitivity, we measured the insulin-stimulated glucose uptake, using a glucose uptake test. Results: We showed that cinnamic acid (CA) and 3-methoxycinnamic acid (3-OMe-CA) restored the proper insulin response. However, 1,2-dicinnamoyl-sn-glycero-3-phosphocholine (1,2-diCA-PC) and 1-cinnamoyl-2-palmitoyl-sn-glycero-3-phosphocholine (1-CA-2-PA-PC) improved insulin sensitivity in insulin-resistant adipocytes even stronger, exhibiting more beneficial effects. Conclusions: The binding of aromatic acids to phosphatidylcholine increases their beneficial effect on insulin sensitivity in adipocytes and expands their potential practical application as nutraceutical health-promoting agents.
DOI:10.3390/nu13103619
- News
- University
- About university
- Authorities
- Structure
- Campus map
- 70 years of UPWr
- Sustainable Development Goals
- Employee Code of Ethics
- International Relations Office
- Library
- 2024 election
- University events
- Students
- Academic calendar for students
- The study regulations
- Accommodation
- Accident Insurance
- Student guide
- Erasmus+
- Student activities
- Young Minds Project
- Study Abroad
- Centre for Foreign Languages, Humanities and Social Sciences
- CEEPUS
- Library
- UPWr Summer School
- Support for Ukrainian and Belarusian students of UPWr
- Research
- Leading scientific disciplines
- Leading Research Groups
- AgrEn – Agriculture-Environment-Natural Resources
- ASc4Future – Animal Science for Future
- BioActiv – Biocatalysis and biological activity
- BioDivRO – Biodiversity and sustainable development in Agriculture and Horticulture
- BioTech@Life – Biotechnology for life and industry
- DroPOWER – Poultry – from stable to table
- Food&Health – Food and Health
- Inno-WET – Innovative diagnostics and veterinary therapy
- Inoter – Smart and modern technologies in agriculture
- LandArch – Landscape architecture
- OncoVet - Veterinary Oncology
- Plants4FOOD – Plants Processing & Technology for Bioactive Food
- SCR – Sustainable Cities and Regions
- SPACEOS– Space And Close Earth Observation Sciences
- THETA – The Biostatistic Group
- WBVG – Waste and Biomass Valorization Group
- WCE – Water-Climate-Environment
- Research projects
- UPWr Base of Knowledge
- Research papers of the week
- Research papers of the week – August 12, 2024
- Research papers of the week – August 5, 2024
- Research papers of the week – July 29, 2024
- Research papers of the week – July 22, 2024
- Research papers of the week – July 15, 2024
- Research papers of the week – July 8, 2024
- Research papers of the week – July 1, 2024
- Research papers of the week – June 24, 2024
- Research papers of the week – June 17, 2024
- Research papers of the week – June 10, 2024
- Research papers of the week – June 3, 2024
- Research papers of the week – May 27, 2024
- Research papers of the week – May 20, 2024
- Research papers of the week – May 13, 2024
- Research papers of the week – May 6, 2024
- Research papers of the week – April 29, 2024
- Research papers of the week – April 22, 2024
- Research papers of the week – April 15, 2024
- Research papers of the week – April 8, 2024
- Research papers of the week – April 1, 2024
- Research papers of the week – March 25, 2024
- Research papers of the week – March 18, 2024
- Research papers of the week – March 11, 2024
- Research papers of the week – March 4, 2024
- Research papers of the week – February 26, 2024
- Research papers of the week – February 19, 2024
- Research papers of the week – February 12, 2024
- Research papers of the week – February 5, 2024
- Research papers of the week – January 29, 2024
- Research papers of the week – January 22, 2024
- Research papers of the week – January 15, 2024
- Research papers of the week – January 8, 2024
- Research papers of the week – January 1, 2024
- Research papers of the week – December 25, 2023
- Research papers of the week – December 18, 2023
- Research papers of the week – December 11, 2023
- Research papers of the week – December 4, 2023
- Research papers of the week – November 27, 2023
- Research papers of the week – November 20, 2023
- Research papers of the week – November 13, 2023
- Research papers of the week – November 6, 2023
- Research papers of the week – October 30, 2023
- Research papers of the week – October 23, 2023
- Research papers of the week – October 16, 2023
- Research papers of the week – October 9, 2023
- Research papers of the week – October 2, 2023
- Research papers of the week – September 25, 2023
- Research papers of the week – September 18, 2023
- Research papers of the week – September 11, 2023
- Research papers of the week – September 4, 2023
- Research papers of the week – August 28, 2023
- Research papers of the week – August 21, 2023
- Research papers of the week – August 14, 2023
- Research papers of the week – August 7, 2023
- Research papers of the week – July 31, 2023
- Research papers of the week – July 24, 2023
- Research papers of the week – July 17, 2023
- Research papers of the week – July 10, 2023
- Research papers of the week – July 3, 2023
- Research papers of the week – June 26, 2023
- Research papers of the week – June 19, 2023
- Research papers of the week – June 12, 2023
- Research papers of the week – June 5, 2023
- Research papers of the week – May 29, 2023
- Research papers of the week – May 22, 2023
- Research papers of the week – May 15, 2023
- Research papers of the week – May 8, 2023
- Research papers of the week – May 4, 2023
- Research papers of the week – April 24, 2023
- Research papers of the week – April 17, 2023
- Research papers of the week – April 11, 2023
- Research papers of the week – April 3, 2023
- Research papers of the week – March 27, 2023
- Research papers of the week – March 20, 2023
- Research papers of the week – March 13, 2023
- Research papers of the week – March 6, 2023
- Research papers of the week – February 27, 2023
- Research papers of the week – February 20, 2023
- Research papers of the week – February 13, 2023
- Research papers of the week – February 6, 2023
- Research papers of the week – January 30, 2023
- Research papers of the week – January 23, 2023
- Research papers of the week – January 16, 2023
- Research papers of the week – January 9, 2023
- Research papers of the week – January 2, 2023
- Research papers of the week – December 26, 2022
- Research papers of the week – December 19, 2022
- Research papers of the week – December 12, 2022
- Research papers of the week – December 5, 2022
- Research papers of the week – November 28, 2022
- Research papers of the week – November 21, 2022
- Research papers of the week – November 14, 2022
- Research papers of the week – November 7, 2022
- Research papers of the week – October 31, 2022
- Research papers of the week – October 24, 2022
- Research papers of the week – October 17, 2022
- Research papers of the week – October 3, 2022
- Research papers of the week – September 26, 2022
- Research papers of the week – September 20, 2022
- Research papers of the week – September 12, 2022
- Research papers of the week – September 5, 2022
- Research papers of the week – August 29, 2022
- Research papers of the week – August 22, 2022
- Research papers of the week – August 15, 2022
- Research papers of the week – August 8, 2022
- Research papers of the week – August 1, 2022
- Research papers of the week - July 25, 2022
- Research papers of the week - July 18, 2022
- Research papers of the week - July 11, 2022
- Research papers of the week - July 4, 2022
- Research papers of the week - June 27, 2022
- Research papers of the week - June 20, 2022
- Research papers of the week - June 13, 2022
- Research papers of the week - June 6, 2022
- Research papers of the week - May 30, 2022
- Research papers of the week – May 22, 2022
- Research papers of the week - May 16, 2022
- Research papers of the week - May 9, 2022
- Research papers of the week - May, 4 2022
- Research papers of the week – April, 25 2022
- Research papers of the week – April 18, 2022
- Research papers of the week – April 11, 2022
- Research papers of the week – April 4, 2022
- Research papers of the week - March 28, 2022
- Research papers of the week - March 21 , 2022
- Research papers of the week - March 14, 2021
- Research papers of the week - March 7th, 2022
- Research papers of the week - Feburary 28, 2022
- Research papers of the week - Feburary 21, 2022
- Research papers of the week - Feburary 14, 2022
- Research papers of the week - Feburary 6, 2022
- Research papers of the week - January 31, 2022
- Research papers of the week – January 24, 2022
- Research papers of the week – January 17, 2022
- Research papers of the week – January 10, 2022
- Research papers of the week – January 03, 2022
- Research papers of the week – December 27, 2021
- Research papers of the week – December 20, 2021
- Research papers of the week – December 13, 2021
- Research papers of the week – December 6, 2021
- Research papers of the week – November 29, 2021
- Research papers of the week – November 22, 2021
- Research papers of the week – November 16, 2021
- Research papers of the week – November 9, 2021
- Research papers of the week – November 2, 2021
- Research papers of the week – October 25, 2021
- Research papers of the week – October 18, 2021
- Research papers of the week – October 11, 2021
- Research papers of the week – October 4, 2021
- Research papers of the week – September 27, 2021
- Research papers of the week – September 20, 2021
- Research papers of the week – September 13, 2021
- Research papers of the week – September 6, 2021
- Research papers of the week – August 30, 2021
- Research papers of the week – August 23, 2021
- Research papers of the week – August 16, 2021
- Research papers of the week – August 9, 2021
- Research papers of the week – August 2, 2021
- Research papers of the week – July 26, 2021
- Research papers of the week – July 19, 2021
- Research papers of the week – July 12, 2021
- Research papers of the week – July 5, 2021
- Research papers of the week – June 28, 2021
- Research papers of the week – June 14, 2021
- Research papers of the week – June 7, 2021
- Research papers of the week – May 31, 2021
- Research papers of the week – May 24, 2021
- Research papers of the week – May 17, 2021
- Research papers of the week – May 10, 2021
- Research papers of the week – May 3, 2021
- Research papers of the week – April 26, 2021
- Research papers of the week – April 19, 2021
- Research papers of the week – April 12, 2021
- Research papers of the week – April 5, 2021
- Research papers of the week – March 29, 2021
- Research papers of the week – March 22, 2021
- Research papers of the week – March 15, 2021
- Research papers of the week – March 8, 2021
- Research papers of the week – March 1, 2021
- Research papers of the week – February 22, 2021
- Research papers of the week – February 15, 2021
- Research papers of the week – February 8, 2021
- Research papers of the week – February 1, 2021
- Research papers of the week – January 25, 2021
- Research papers of the week – January 18, 2021
- Research papers of the week – January 11, 2021
- Research papers of the week – January 4, 2021
- Research papers of the week – December 21, 2020
- Research papers of the week – December 14, 2020
- Research papers of the week – December 7, 2020
- Research papers of the week – November 30, 2020
- Research papers of the week – November 23, 2020
- Research papers of the week – November 16, 2020
- Research papers of the week – November 9, 2020
- Research papers of the week – November 2, 2020
- Research papers of the week – October 26, 2020
- Research papers of the week – October 19, 2020
- Research papers of the week – October 12, 2020
- Research papers of the week – October 5, 2020
- Research papers of the week – September 28, 2020
- UPWr Doctoral School
- Research collaboration offers
- Post-doc offer
- Offers for UA reseachers
- Offers for UA reseachers – Leading Research Groups (UPWr)
- Innovative diagnostics and veterinary therapy – Inno-WET
- Agriculture-Environment-Natural Resources – AgrEn
- Biotechnology for life and industry – BioTech@Life
- Biocatalysis and biological activity – BioActiv
- Reg-Med-Lab – Marycz Lab
- Sustainable Cities and Regions – SCR
- Space And Close Earth Observation Sciences – SpaceOS
- General veterinary, preclinical and hygienic science – WET-PPH
- Waste and Biomass Valorization Group – WBVG
- Offers for UA researchers outside of UPWr
- Programmes and Grants
- Offers for UA reseachers – Leading Research Groups (UPWr)
- The Excellence Initiative – Research University
- European Charter for Researchers
- Collaboration
- Admission
- For employees